Shumiya cataract rat

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August undefined, 2024

Webchestnut (Trapa bispinosa Roxb.) extract (TBE) on cataracts and the expression of antioxidant-related genes were assessed in Shumiya cataract rats (SCRs). LU+TBE or castor oil (COil) as a control was administered to 6- or 9-week-old cataractous SCRs and noncataractous SCRs via a feeding needle for 3 or 4 weeks. WebNov 1, 1993 · The Shumiya cataract rat (SCR) is a hereditary cataract model in which lens opacity appears spontaneously in the nuclear and perinuclear portions at 11–12 weeks of …

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WebJul 4, 2024 · The Shumiya cataract rat (SCR) is a hereditary cataractous rat strain, which is classed as two models (non-cataract type, SCR-N, and cataractous type, SCR-C) . SCR-N (ctr1 × ctr1, Ctr2 × Ctr2), without the mutations causing premature cataracts, maintains a transparent lens, although slight lens structure collapse was observed at 8–12 weeks of … WebApr 1, 2007 · Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat. Mori M, Li G, Abe I, Nakayama J, Guo Z, Sawashita … population of harlem new york

Delay of cataract development in the Shumiya cataract rat by the ...

WebAug 20, 2024 · The lens of cataract rats had α-A crystallin expression levels increased by 35% when compared to the control (Fig. 2E). ... Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat. J. Clin. Invest., 116 (2006), pp. 395-404. CrossRef View Record in Scopus Google Scholar WebFeb 1, 2006 · The Shumiya cataract rat (SCR) and normal control rat strains of NC1 and NC2 were established. Mean cataract appearance in adult SCR rats was 66.7%, and embryo … http://www.anim.med.kyoto-u.ac.jp/model/shumiya/SCR.html population of harlem ga

Lanosterol Synthase Pathway Alleviates Lens Opacity in Age ... - Hindawi

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WebJul 10, 2003 · Methods Selenite cataract was induced in Sprague–Dawley rats by five subcutaneous injections of sodium ... activity in selenite nuclear cataract 20 and Shumiya cataract 21 in rat. ... WebOct 25, 2024 · By positional cloning and genotyping in Shumiya cataract rats, Mori et al. (2006) identified hypomorphic mutations in the Lss gene and the Fdft1 gene, as well as a null mutation in Lss.Cataract onset was associated with the specific combination of Lss and Fdft1 mutant alleles that decreased cholesterol levels in cataractous lenses to about 57% … sharlene griffith sharlene hamilton lpc

"WebCataract is a phenomenon in which the eye becomes opaque resulting in severe visual impairment, and senile cataract is the most common cause of blindness in the world. We … " - Shumiya cataract rat

Shumiya cataract rat

Lanosterol synthase mutations cause cholesterol deficiency …

WebSix-week-old Shumiya cataract rats were used to perform experiments. The right eye of each rat was injected with TAT-HA-Prdx6 WT-NPs or TAT-HA-Prdx6 K122/142R-NPs, whereas the left eyes were administered with TAT-HA-Prdx6 Inactive-mutant-NPs. The subconjuctival injection was made using micro-syringes fitted with 30-gauge needles. WebOct 1, 2001 · Aminoguanidine-treatment results in the inhibition of lens opacification and calpain-mediated proteolysis in Shumiya cataract rats (SCR). Inomata M, Hayashi M, …

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Webcataract drug for human cataracts has not yet been intro-duced. In studies to develop anti-cataract drugs, the selection of the experimental animal is very important. The UPL rat (UPLR), Shumiya cataract rat (SCR) and Ihara cataract rat (ICR/f; ICR) are hereditary cataractous strains, and it has been shown that these rats provide useful models ... WebWe previously found that the increases in Ca 2+ content in the lenses of three hereditary cataract model rats, UPL rat (UPLR), Shumiya cataract rat (SCR) and Ihara cataract rat (ICR), are inhibited by aminoguanidine, a selective inhibitor of inducible nitric oxide synthase, and that the mechanisms of Ca 2+ enhancement in these rat models differ. In this study, we …

Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 WebLens reconstruction after mature cataract in SCR rat. @article{Okano1999LensRA, title={Lens reconstruction after mature cataract in SCR rat.}, author={Takuya Okano and Shigekazu Uga and S. Ishikawa and Akiko Hara and Seigou Shumiya}, journal={Japanese journal of ophthalmology}, year={1999}, volume={43 5}, pages={ 363-7 } }

WebJul 4, 2024 · Ophthalmic In Situ Gelling System Containing Lanosterol Nanoparticles Delays Collapse of Lens Structure in Shumiya Cataract Rats. Next Article in Special Issue. Studies on the Effect of Oil and Surfactant on the Formation of Alginate-Based O/W Lidocaine Nanocarriers Using Nanoemulsion Template. WebPurpose: To conduct a long-term observation study of SCR rats that had developed a mature cataract at 11 weeks of age at 3-month intervals until the rats were 12 months old. Methods: Lenses of 15 rats were examined with both light and electron microscopes.. Results: At 12 weeks, opacity was observed in the perinuclear zone and the cortical intermediate layer.

WebThe Shumiya cataract rat (SCR) is a hereditary cataractous strain. It is thought that the continuous occur-rence of poorly differentiated epithelial cells at the bow area of the lens …

Web遺伝性白内障ラットのSCR（Shumiya Cataract Rat）は高血圧自然発症ラットに肥満遺伝子を導入したコンジェニック系のSHR-faを育成中、成熟期に核性白内障をおこすライン … population of harper texasWebAug 4, 2024 · Six-week-old Shumiya cataract rats were used to perform experiments. The right eye of each rat was injected with TAT-HA-Prdx6 WT-NPs or TAT-HA-Prdx6 K122/142R-NPs, whereas the left eyes were administered with TAT-HA-Prdx6 Inactive-mutant-NPs. The subconjuctival injection was made using micro-syringes fitted with 30-gauge needles. sharlene hamrickWebThe Shumiya cataract rat (SCR) is a hereditary cataract model in which lens opacity appears spontaneously in the nuclear and perinuclear portions at 11-12 weeks of age. population of harrah okWebFeb 1, 2024 · @article{Nagai2024TheII, title={The Intravitreal Injection of Lanosterol Nanoparticles Rescues Lens Structure Collapse at an Early Stage in Shumiya Cataract Rats}, author={Noriaki Nagai and Yuya Fukuoka and Kanta Sato and Hiroko Otake and Atsushi Taga and Mikako Oka and Noriko Hiramatsu and Naoki Yamamoto}, journal={International … population of harrah oklahomaWebShumiya cataract rat (SCR) is a hereditary cataractous rat strain that develops cataract at approximate 11 weeks of age . Lss gene is mutated in SCR and is the major gene for cataract onset [ 19 ]. In humans, two distinct homozygous LSS missense mutations (W581R and G588S) happen in two families with extensive congenital cataracts, which impairs key … population of harlingen texasWebWe demonstrate a delaying effect of deep-sea drinking water (DDW) containing enhanced magnesium ion (Mg 2 +) and calcium ion (Ca 2 +) concentrations on cataract … population of harlow essexWebApr 7, 2024 · By positional cloning and genotyping in Shumiya cataract rats, Mori et al. (2006) identified hypomorphic mutations in the Lss gene and the Fdft1 gene (), as well as a null mutation in Lss.Cataract onset was associated with the specific combination of Lss and Fdft1 mutant alleles that decreased cholesterol levels in cataractous lenses to about 57% … population of harrington nsw