Mechanisms of resistance to cisplatin

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August undefined, 2024

WebThe first is the reduction in the accumulation of the drug intracellular. 17 Reduced accumulation of drug is a significant mechanism that results into resistance and reductions in accumulation of drugs by a factor of between 20% to70% could cause resistance of cisplatin by a factor of 3 to 40 fold respectively. 18 However as Koberle et al ... WebJul 1, 2001 · Mechanisms of resistance to cisplatin. The use of cisplatin in cancer chemotherapy is limited by acquired or intrinsic resistance of cells to the drug. Cisplatin enters the cells and its chloride ligands are replaced by water, forming aquated species that react with nucleophilic sites in cellular macromolecules.

Mechanisms of resistance to cisplatin and carboplatin

WebApr 12, 2024 · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need alternative … WebFeb 25, 2024 · The resistance of ovarian cancer cells to chemotherapeutic mechanisms is rather complex and includes multidrug resistance, DNA damage repair, cell metabolism, oxidative stress, cell cycle regulation, cancer stem cells, immunity, apoptotic pathways, autophagy and abnormal signaling pathways. richmond virginia school system

Mechanism of resistance to cisplatin Request PDF - ResearchGate

WebMar 22, 2024 · EMT-associated chemotherapy resistance in SCC. To investigate the role and the mechanisms of resistance to therapy in EMT tumour cells in vivo, we used a genetically induced mouse model of skin SCCs combining the expression of oncogenic Kras (Kras G12D) with the deletion of Trp53 and the expression of a YFP reporter in hair follicle … WebApplications of Machine Learning to Predict Cisplatin Resistance in Lung Cancer . Fulltext; Metrics; Get Permission; Cite this article; Authors Gao Y, Lyu Q, Luo P , Li M, Zhou R, Zhang … WebPDF) Review on Pharmacology of Cisplatin: Clinical Use, Toxicity and Mechanism of Resistance of Cisplatin ResearchGate. PDF) Cisplatin: An old drug with a newfound efficacy – from mechanisms of action to cytotoxicity. CyberLeninka. On the Discovery, Biological Effects, and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy – topic ... richmond virginia secretary of state

Molecular Mechanisms of Platinum Resistance in Ovarian Cancer

Cisplatin research paper - connectioncenter.3m.com

WebAug 1, 2001 · Knowledge of the mechanism of action of cisplatin has improved our understanding of resistance. Decreased intracellular concentration due to decreased drug uptake, increased reflux or... WebMechanisms of resistance to cisplatin Alan Eastman Chapter 115 Accesses 29 Citations Part of the Cancer Treatment and Research book series (CTAR,volume 57) Abstract Cisplatin has become a major clinical drug because of its … richmond virginia section 8WebAug 25, 2024 · Many lncRNAs have been associated with these mechanisms of cisplatin resistance (Fig. 1) and are summarised here into four major groups. Fig. 1: Resistance to cisplatin mediated by lncRNAs. red roof quilt shop

"WebMar 17, 2016 · The majority of ovarian tumors eventually recur in a drug resistant form. Using cisplatin sensitive and resistant cell lines assembled into 3D spheroids we profiled gene expression and identified candidate mechanisms and biological pathways associated with cisplatin resistance. OVCAR-8 human ovarian carcinoma cells were exposed to sub … " - Mechanisms of resistance to cisplatin

Mechanisms of resistance to cisplatin

WebMechanisms of resistance to cisplatin Alan Eastman Chapter 115 Accesses 29 Citations Part of the Cancer Treatment and Research book series (CTAR,volume 57) Abstract … WebFeb 28, 2024 · However, the principal mechanisms by which 13 and, above all, 18 overcome cisplatin resistance rely on three different possible mechanisms: the inhibition of endogenous P-gp expression, a transporter that enables the active efflux of the drug from the cancer cells; the generation of ROS inside the cells that can reduce GSH levels, a …

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WebPostulated mechanisms of cisplatin drug resistance include decreased intracellular accumulation of cisplatin, increased intracellular levels of certain sulfur-containing macromolecules, and increased DNA repair. 1,3. Decreased Intracellular Accumulation If cisplatin cannot accumulate in the cell, it cannot reach the DNA found inside the cell ... WebApr 12, 2024 · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need alternative therapy options. Researchers at ...

WebJul 1, 2001 · Postulated mechanisms of resistance to cisplatin include the following: reduced intracellular accumulation of cisplatin which may arise because of decreased … WebApplications of Machine Learning to Predict Cisplatin Resistance in Lung Cancer . Fulltext; Metrics; Get Permission; Cite this article; Authors Gao Y, Lyu Q, Luo P , Li M, Zhou R, Zhang J , Lyu Q. Received 21 July 2024. Accepted for publication 3 September 2024

WebOct 22, 2024 · 2.2 Epigenetic Mechanisms and Cisplatin Resistance in OSCC The epigenetic modifications include several different forms such as methylation, histone modification, and regulation of non-coding RNAs. Genetic mechanisms and epigenetic mechanisms influence each other and work together to obtain the characteristics of cancer ( 26 ). WebMechanisms associated with the expression of cisplatin resistance in a human ovarian tumor cell line following exposure to fractionated X-irradiation in vitro. Carcino-genesis 13: …

WebSep 5, 2011 · There are at least two mechanisms by which cancer cells elude the cytotoxic potential of cisplatin before it binds to cytoplasmic targets and DNA: (1) a reduced …

richmond virginia seafoodWebJul 1, 2007 · Resistance has also been associated with abnormal sorting of some lysosomal proteins and cisplatin transporters into an exosomal pathway [75], and with drug … richmond virginia sex offender registryWebVarious mechanisms of tumor resistance to DDP have been described, and, most recently, these mechanisms have been classified as follows: (1) pre-target resistance (before cisplatin binds to DNA), (2) target resistance (directly associated with DNA-cisplatin adducts), (3) post-target resistance (associated with apoptosis caused by DDP-mediated ... red roof quispamsisWebApr 12, 2012 · Molecular mechanisms of cisplatin resistance. Platinum-based drugs, and in particular cis-diamminedichloroplatinum(II) (best known as cisplatin), are employed for … richmond virginia section 8 applicationWebMar 28, 2024 · Objective: Cisplatin resistance development is a major obstacle in ovarian cancer treatment. One of the most important mechanisms underlying cisplatin resistance is drug detoxification by glutathione. red roof queensburyWebJan 20, 2024 · Resistance to platinum-containing drugs has been associated to several mechanisms, including alteration in drug efflux (through for example the modulation of the copper transporter CTR-1 expression) [1,2,3,4,5], alteration in intracellular proteins able to bind and sequester Pt (as for example GSH) [6,7,8,9], and altered expression of … richmond virginia scotts additionWebJul 28, 2024 · Inside the tumor cell, decreased drug import, increased drug export, increased drug inactivation by detoxification enzymes, increased DNA damage repair, and inactivated cell death signaling are major mechanisms leading to cisplatin resistance. red roof ranch llc