Chemical uncoupler
WebJul 2, 2012 · Although uncoupling metabolism is a possible measure to reduce sludge generation during the activated sludge process for treating organic wastewater, the fate … WebBiological description. Potent mitochondrial oxidative phosphorylation uncoupler (IC 50 = 20 nM). Disrupts ATP synthesis by transporting protons across mitochondrial inner …
Chemical uncoupler
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WebSep 15, 2024 · Uncoupler is capable of disrupting the equilibrium concentration of proton on two sides of the bacterial cytoplasm membrane and inducing the reduction of PMF [13]. The addition of uncouplers is an effective way to induce the energy uncoupling which means the tight coupling of anabolism and catabolism is disrupted. WebUncoupling it results in chemical energy from diet and energy stores such as triglycerides being wasted as heat with minimal regulation, leading to dangerously high body temperatures that may develop into heatstroke. …
WebAug 19, 2016 · The study of Long et al. reawakens the promise of chemical-based mitochondrial uncoupling as a therapeutic strategy for obesity and obesity-associated diseases. Recent progress has been made toward developing liver-specific DNP derivatives or milder mitochondrial uncouplers that are effective in treating obesity and obesity … WebAug 30, 2024 · Uncoupling of mitochondrial respiration by chemical uncouplers has proven effective in ameliorating obesity, insulin resistance, and hyperglycemia. However, development of uncoupler-based therapy ...
WebApr 4, 2024 · SMP production by activated sludge in the presence of a metabolic uncoupler, 3,3′,4′,5-tetrachlorosalicylanilide (TCS). Applied Microbiology and Biotechnology, 95(5): 1313–1321. Article CAS Google Scholar Liu Y (2000). Effect of chemical uncoupler on the observed growth yield in batch culture of activated sludge. WebDec 20, 2002 · Uncouplers that have been studied for reducing sludge production include various nitro and chlorophenols (Mayhew and Stephenson, 1998;Low et al., 2000; Hiraishi and Kawagishi, 2002). More...
WebNov 28, 2013 · Chemical 'mitochondrial uncouplers' are lipophilic weak acids that transport protons into the mitochondrial matrix via a pathway that is independent of ATP synthase, thereby uncoupling nutrient oxidation from ATP production. Mitochondrial uncouplers also lessen the proton motive force across the mitochondrial inner membrane and thereby …
WebAn uncoupling protein ( UCP) is a mitochondrial inner membrane protein that is a regulated proton channel or transporter. An uncoupling protein is thus capable of dissipating the proton gradient generated by NADH … black iphone lockscreenWebAug 2, 2013 · Chemical uncouplers have been shown to reduce excess sludge production, disassociating the energy coupling between catabolism and anabolism. These metabolic uncouplers may be organic compounds ... black iphone poshmarkWebChemical Uncouplers Oxidative phosphorylation in plants is sensitive to chemical uncouplers such as dinitrophenol (DNP), carbonyl cyanide p … black iphone iconWebNational Center for Biotechnology Information black iphone pngWebDinitrophenol (DNP) is a chemical that acts as an uncoupling agent, making the inner mitochondrial membrane leaky to protons. It was used until 1938 as a weight-loss drug. … gamsat revisionWebNov 29, 2024 · A group of lipophilic weak acids, called metabolic uncouplers, are known to induce metabolic uncoupling due to their ability to transport H + through an H + -impermeable membrane. The ability of the uncouplers to transport protons through the impermeable membrane is termed as protonophoric action (Fig. 2 ). gamsat s2 redditWebMay 1, 2000 · The presence of chemical uncoupler in the culture medium can cause significant energy spilling. It appears that energy spilling may be an effective pathway for bacteria to protect themselves... black iphone movie